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2014.03.03 [배움] Anitplatelets

2014. 3. 3. 00:33

[배움] Anitplatelets

	Cautions	Hepatic impairment	Renal impairment	Loading dose	Maintenance dose
Clopidogrel(Plavix)	* Contraindications Hypersensitivity Active pathologic bleeding * Cautions discontinue 5-10d. before surgery allergic to aspirin caution in A.fib	Use caution	Not necessary	600mg	150 for 7days, 75mg for MD
Prasugrel(Effient)	* Contraindications Hypersensitivity Active pathologic bleeding Prior TIA or stroke * Cautions BW<60kg->5mg/day Bleeding diathesis TTP reported (in 2 Wks.) Caution with Anticoagulant, NSAIDs, Fibrinolytics	In severe: not studied mild-to-moderate: not Necessary	Not necessary	60mg	10mg
Ticagrelor(Brilinta)	* Contraindications Hypersensitivity History of Intra Cranial Hemo. Active pathologic bleeding Severe hepatic impairment * Cautions increase risk of bleeding discontinue 5d before surgery aspirin dose < 100mg/day Dyspnea reported(resolved) Avoid interruption	Contraindicated in severe state Caution in moderate state	NO dose adjustment	180mg	90mg q12hr

*Maximal platelet aggregation, Acute Coronary Syndrome 후 mortality 로 봤을 때
Ticagrelor > Pragsugrel > Clopidogrel

*In patients ≥ 75 years of age, Effient is generally not recommended, because of the increased risk of fatal and intracranial bleeding and uncertain benefit, except in high-risk situations (patients with diabetes or a history of prior MI) where its effect appears to be greater and its use may be considered

REFERENE

1. Clopidogrel, Prasugrel, Tacegerlor, ACC, 2013

2. Medscape

3. Prescribing informations

brilinta prescribing information.pdf