'Brilinta'에 해당되는 글 1건

  1. 2014.03.03 [배움] Anitplatelets

 

Cautions

Hepatic impairment

Renal impairment

Loading dose

Maintenance dose

Clopidogrel(Plavix)

* Contraindications
Hypersensitivity
Active pathologic bleeding
* Cautions
discontinue 5-10d. before surgery
allergic to aspirin
caution in A.fib

Use caution

Not necessary

600mg

150 for 7days,
75mg for MD

Prasugrel(Effient)

* Contraindications
Hypersensitivity
Active pathologic bleeding
Prior TIA or stroke
* Cautions
BW<60kg->5mg/day
Bleeding diathesis
TTP reported (in 2 Wks.)
Caution with
Anticoagulant, NSAIDs, Fibrinolytics

In severe: not studied
mild-to-moderate: not Necessary

Not necessary

60mg

10mg

Ticagrelor(Brilinta)

* Contraindications
Hypersensitivity
History of Intra Cranial Hemo.
Active pathologic bleeding
Severe hepatic impairment
* Cautions
increase risk of bleeding
discontinue 5d before surgery
aspirin dose < 100mg/day
Dyspnea reported(resolved)
Avoid interruption

Contraindicated in severe state

Caution in moderate state

NO dose adjustment

180mg

90mg q12hr

 


 


*Maximal platelet aggregation, Acute Coronary Syndrome mortality 로 봤을 때
 Ticagrelor > Pragsugrel > Clopidogrel

 

*In patients ≥ 75 years of age, Effient is generally not recommended, because of the increased risk of fatal and intracranial bleeding and uncertain benefit, except in high-risk situations (patients with diabetes or a history of prior MI) where its effect appears to be greater and its use may be considered

 

REFERENE

1.  Clopidogrel, Prasugrel, Tacegerlor, ACC, 2013

2. Medscape

3. Prescribing informations


brilinta prescribing information.pdf


Effient prescribing informations.pdf


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